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Contraindicated (1)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with strong CYP3A4 inducers; these medication cut down exposure to vandetanib by nearly 40%.pentobarbital will lessen the extent or impact of fosaprepitant by impacting hepatic/intestina